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From Controlled Trial to Community Adoption: The Multisite Translational Community Trial

机译:从对照试验到社区采用:多站点转化社区试验

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摘要

Methods for translating the findings of controlled trials, such as the Diabetes Prevention Program, into real-world community application have not been clearly defined. A standardized research methodology for making and evaluating such a transition is needed. We introduce the multisite translational community trial (mTCT) as the research analog to the multisite randomized controlled trial. The mTCT is adapted to incorporate the principles and practices of community based participatory research and the increased relevance and generalizability gained from diverse community settings. The mTCT is a tool designed to bridge the gap between what a clinical trial demonstrates can work in principle and what is needed to make it workable and effective in real-world settings. Its utility could be put to the test, in particular with practice-based research networks such as the Prevention Research Centers. (Am J Public Health. Published online ahead of print June 16, 2011: e1-e11. doi:10.2105 AJPH.2010.300104).
机译:尚未明确定义将诸如糖尿病预防计划等对照试验的结果转化为现实世界的方法。需要用于进行和评估这种过渡的标准化研究方法。我们介绍多站点翻译社区试验(mTCT)作为多站点随机对照试验的研究类似物。 mTCT适用于纳入基于社区的参与性研究的原则和实践,以及从各种社区环境中获得的相关性和普遍性的增强。 mTCT是一种工具,旨在弥合临床试验证明的原理可以发挥作用,以及使其在实际环境中可行和有效所需的条件之间的差距。它的效用可以进行测试,尤其是通过基于实践的研究网络(如预防研究中心)进行测试。 (Am J Public Health。于2011年6月16日在网上提前发布:e1-e11。doi:10.2105 AJPH.2010.300104)。

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